Interestingly, a recent study in human esophageal cancer cell lines demonstrated that phosphorylation of MZF1 serine 27 by constitutively active casein kinase 2 (CK2), which is often upregulated in cancers, mediates their epithelial to mesenchymal transition by inducing the expression of N-cadherin [60]. This evidence concerns the gene MZF1 and esophageal cancer.