A good example of a cancer drug that targets a transcription factor is thalidomide, an antiemetic drug from the 1950s that has been repurposed as a novel treatment against hematological malignancies and which functions by inactivating zinc finger transcription factors Ikarios (IKZF1) and Aiolos (IKZF3) through their destabilization [1,2]. This evidence concerns the gene IKZF3 and cancer.