PAK4 and breast carcinoma: In a study conducted in MCF7 breast cancer cells with inducible expression of constitutively active ErbB2, ErbB2 activation was shown to increase the transcriptional activity of MZF1 via a signaling network that involves TGFβ receptors 1 and 2 (TGFBR1 and 2), ERK2, PAK4 (PAK5 and PAK6), cdc42 binding protein beta kinase (CDC42BPB), and PKCα (PRKCA) [7].