Moreover, as our previous studies by James, A.D. et al. [9,10] suggested that MIA PaCa-2 cells are more reliant on glycolytically–derived ATP than the related PANC-1 cells, this makes MIA PaCa-2 an ideal cellular model to examine the role of PMCA4 on PDAC cancer hallmarks, particularly the metabolic shift towards glycolysis. The gene discussed is ATP2B4; the disease is cancer.