Although the molecular mechanisms are unclear, the direct interaction between Gata4 and Zfpm2 are thought to be required for differentiation of testis cell lineages (Bouma, Washburn, Albrecht, & Eicher, 2007), yet just a handful of reports have found GATA4 and ZFPM2 variants in humans with DSD. This evidence concerns the gene ZFPM2 and disorder of sexual differentiation.