TF and neoplasm: TF promotes tumor growth, migration, and angiogenesis, independent of the coagulation cascade, via activation of protease‐activated receptor (PAR)2.11 Thrombin promotes tumor growth, angiogenesis, and metastasis through PAR112, 13 and through fibrin generation, for example by shielding tumor cells from immune surveillance.14 We hypothesize that in tumor stroma a process similar to wound healing occurs, with TF and its downstream effector molecules promoting cancer progression.