Increased stromal gene expression of the thrombin receptor PAR3 was associated with early recurrence in breast cancer.6 In triple negative cancers, genes enriched in stroma compartment (compared to the Cancer Genome Atlas) included upregulation of genes for PAR1 as well as Coagulation Factor XIIIa which is activated (from XIII) by thrombin.23 Here, F2R is linked to breast cancer.