Successful DMD gene editing also has been achieved using clustered regularly interspaced short palindromic repeats (CRISPR) coupled with an enzyme, typically caspase (Cas)-9, in cell culture, the DMD murine model (mdx) [5–10], and, most recently, in the deltaE50-MD dog model for DMD [11]. This evidence concerns the gene DMD and Duchenne muscular dystrophy.