Diabetic nephropathy (DN) is the most common cause of chronic kidney disease (CKD), and the risk for end-stage renal disease (ESRD) is approximately 12-fold higher in diabetic patients than in non-diabetic patients.[1–4] Guidelines have recommended measuring the urine albumin-creatinine ratio (uACR) and estimated glomerular filtration rate (eGFR) annually in diabetic patients.[5, 6]. The gene discussed is ALB; the disease is chronic kidney disease.