S100A8 and infection: Because the roles of MRP14 in inflammatory responses may differ in mice with different genetic backgrounds [29], we first evaluated the protective role of MRP14 in infection of BALB/c mice with L. major. In the ear infected with L. major, accumulation of MRP14+ cells and MRP8+ cells were induced (Fig 1), and the accumulation seemed to be dependent in part on endogenous MRP14 (Fig 3).