SOX3 and spina bifida: Thus, altered expression of MIR505 could be involved in the occurrence of spina bifida in the proband from the Chinese family with CGH that is associated with a deletion of Xq27.1 and insertion of 5q35.3 (29), although it also remains possible that it is the deletion-insertion associated disruption of SOX3 itself that is responsible for spina bifida, as SOX3 dysfunction has been reported to be linked to neural tube defects in human (24, 25).