The meta—analytic results showed that the pooled overall diagnostic sensitivity, specificity, LR+, LR− and 95% CIs about PCA3 for predicting significant PCa were 0.68 (0.64-0.72), 0.72 (0.68-0.75), 2.41 (2.16-2.69), 0.44 (0.40-0.49), respectively (Figure-2). Here, PCA3 is linked to posterior cortical atrophy.