CXCL12 and myeloid sarcoma: During neuroinflammation, such as in EAE and MS, however, scavenging of CXCL12 from the BBB surface as well as disrupted polarity of CXCL12 across CNS endothelium promotes immune cell infiltration into the CNS parenchyma (Cruz‐Orengo et al., 2014; Cruz‐Orengo, Holman, et al., 2011; McCandless et al., 2008).