NFKB1 and metachromatic leukodystrophy: During acute demyelination in MS, progressive multifocal leukoencephalopathy, metachromatic leukodystrophy, and subacute infarction, astrocytes remove myelin via receptor‐mediated endocytosis, which results in activation of the transcription factor NF‐κB and further release of chemokines (Ponath et al., 2017).