AKT1 and diabetes mellitus: Naturally, Akt phosphorylation-dependent (pAkt) pathways are implicated in multiple human diseases, such as many types of cancers (Engelman, 2009; Hemmings and Restuccia, 2012), diabetes (Whiteman et al., 2002), and psychiatric disorders (Gilman et al., 2012; McGuire et al., 2014).