ACTA1 and Hepatic fibrosis: Hepatic fibrosis is the wound‐healing process in response to chronic liver injury.1 Hepatic stellate cell (HSC) constitutes the accumulation of extracellular matrix (ECM) once they activated.2 The activated HSC expresses a variety of factors such as transforming growth factor‐β1 (TGF‐β1), which stimulate the HSC activation, and secrete collagens and smooth muscle α‐action (α‐SMA).3 This study discusses the molecular and cellular mechanisms of HSC activation and offers a novel approach for liver fibrosis therapy.