The activity of JMJD6 is regulated by hypoxia, iron and 2OG availability.31 The upregulation of JMJD6 can be induced by hypoxia.53 The hypoxia‐inducible factor (HIF) hydroxylases are the major regulators of the hypoxia response, probably in animals ranging from nematode worms to man.54 Hypoxia can upregulate metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1), a long non‐coding RNA associated with cancer progression and metastasis.55 JMJD6 can be positively regulated by MALAT1 through MALAT1/miR‐125/JMJD6 axis. This evidence concerns the gene JMJD6 and cancer.