TP53 and colon carcinoma: Jumonji domain‐containing protein 6 has been reported to interact with p53 and participate in its posttranslational modification.16 Perturbations in p53 signalling pathways are thought to play an important role in the development of cancer, and mutations leading to loss of wild‐type p53 activity are often detected in many different types of cancer.76 In human colon carcinoma HCT116 cells, JMJD6 is physically associated with the tumour suppressor p53, and the C‐terminal fragment of p53 (from residues 290 to 393) is required for the binding of p53 to JMJD6.