As a member of homeobox superfamily, homeobox‐containing B9 (HOXB9) has been demonstrated to function in embryonic development and human cancer progression.134, 135 In contrast to the wild‐type HOXB9, HOXB9 acetylated at lysine 27 decreases its ability to promote the migration and growth of lung cancer cells in mice through direct occupying the promoter of its target gene JMJD6 and suppressing the transcription of JMJD6.72 Here, JMJD6 is linked to cancer.