Through thedatabase analysis of circular RNA reported by Memczak et al,11 we found that cir-ITCH spans several E3 ubiquitin (Ub) exons.9,12 The reports indicated that cir-ITCH has binding sites in manymiRNAs, such as miR-214, miR-17, miR-7, miR-216b, and miR-128, suggesting that it may act asa miRNA sponge.10 It has been found that cir-ITCH plays an inhibitory role in bothoesophageal squamous cell carcinoma and colorectal cancer and also suppresses lung cancer proliferation.12,13,14. This evidence concerns the gene ITCH and colorectal cancer.