CCN2 and cardiac hypertrophy: Our results confirm previous work in rodent models of hypoxia, with respect to expression of fetal genes (NPPA, NPPB), fibrotic genes (TGFB2, CTGF, LTBT2), and genes marking cardiac hypertrophy (NPPB, THBS4) in the heart after exposure to hypoxia (Baertschi et al., 1986; Lew & Baertschi, 1989; Partovian et al., 1998; Toth et al., 1994).