SELE and metabolic dysfunction-associated steatotic liver disease: In the present study, we showed that (a) NAFLD severity, in particular the inflammatory stage, was associated with hepatic E‐selectin expression; (b) E‐selectin mRNA expression in liver, but not in VAT and muscle, was associated with plasma sE‐selectin levels and (c) NAFLD susceptibility genes and liver parenchyma damage (reflected by plasma ALT levels) were associated with plasma sE‐selectin levels, independent of potential confounding factors.