SELE and metabolic dysfunction-associated steatotic liver disease: Plasma soluble E‐selectin (sE‐selectin) and vascular cell adhesion molecule‐1 (sVCAM‐1) have often been used as biomarkers of systemic endothelial activation.4, 5, 6 Of interest, we and others have previously shown that NAFLD is a significant determinant of plasma endothelial biomarkers, in particular sE‐selectin.7, 8 Furthermore, it has been shown that hepatic E‐selectin is actively involved in hepatic neutrophil infiltration in mice exposed to chronic plus binge ethanol feeding.9