The relationship between biomarkers of NAFLD, that is, plasma aminotransferase (ALT) and NAFLD susceptibility genes (rs738409 [PNPLA3] and rs1260326 [GCKR]), and plasma sE‐selectin was studied in the combined CODAM (n = 571) and Hoorn (n = 694) studies. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.