Wu et al reported that PLR combined with CEA can produce larger AUC in gastric cancer diagnosis.10 For early‐stage CRC, Peng et al found that PLR combined with CEA provided a higher diagnostic efficacy than PLR or CEA alone and could be used as a CRC diagnostic biomarkery.21 According to the results of previous studies and our findings, combining PLR or HPR with CEA may be a promising early diagnosis biomarker for rectal cancer. Here, CEACAM5 is linked to gastric cancer.