Nonetheless, in our hands, selective dopamine D2 receptor antagonists impair social novelty discrimination and NOR [54] consistent with the lack of effect or worsening of cognition seen with current antipsychotics in patients with schizophrenia, while the dopamine partial agonist cariprazine reversed the isolation-rearing induced impairment in NOR [49]. This evidence concerns the gene DRD2 and schizophrenia.