During ischemia, dephosphorylated cMyBP-C was more prone to proteolysis than phosphorylated cMyBP-C (Sadayappan et al. 2005) and recently 29 kDa cMyBP-C fragments released during ischemia were shown to be useful early indicators of myocardial infarction (Govindan et al. 2013; Lyngbakken et al. 2019). This evidence concerns the gene MYBPC3 and myocardial infarction.