The above findings suggest a link between apoptotic and necroptotic machinery at least in SH-SY5Y cells exposed to oxidative stress stimulus since in another cell damage model of neuroblastoma cells (induced by stenodactylin) there was a complete prevention of cell death by combined treatment with caspase inhibitor (Z-VAD-fmk) plus catalase or Nec-1 (Polito et al. 2016). The gene discussed is PCSK1; the disease is neuroblastoma.