HER4 signalling is pivotal in myocardial development, ventricular growth, proliferation and functional homeostasis of the adult heart and together with HER2 and their ligand Neuregulin-1 exert protective roles in the myocardium, e.g. enhancing cardiac repair mechanisms, reduce infarction-induced apoptosis and improve left ventricular ejection fraction [42]. Here, ERBB4 is linked to infarction.