CXCR3 and neoplasm: Interestingly we found the CXCL9, -10,-11/CXCR3 (fold change 9.5, 8, 14 and 2.5 with p = 0.0005–0.0001) axis to be significantly upregulated in the tumor tissue, promoting cancer cell proliferation and metastasis (autocrine axis) (Fig. 1b).