In contrast, uptake outside the ischemic area was not observed in any of our patients with stroke of non-vasculitis origin or moyamoya disease confirming preclinical and clinical imaging studies that TSPO is highly expressed by microglia/macrophages in the infarct core and peri-infarct areas in ischemic stroke with non-vasculitis origin [30–35]. This evidence concerns the gene TSPO and ischemic stroke.