Bruun et al. (2012) were able to demonstrate an upregulation in matrix metalloproteinase 9 and 12 in porcine lung infections, whereas matrix metalloproteinases often work as the first barrier in infections with gram-negative bacteria, and SPONDIN-1 can supposedly mediate matrix metalloproteinase 9 expression (Lee et al. 2016). The gene discussed is MMP9; the disease is infection.