Moreover, analysis results from Kaplan–Meier Plotter Pan-cancer RNA sequencing public webserver (http://kmplot.com/analysis/index.php?p=service&cancer=pancancer_rnaseq) indicated that higher level of FOXD2-AS1 was significantly associated with poorer OS in all head and neck cancer cases, and stage IV head and neck cancer cases (Fig. 1d–f). This evidence concerns the gene FOXD2 and head and neck cancer.