Moreover, immunohistochemistry (IHC) analysis and terminal deoxynulceotidyl transferase nick-end-labeling (TUNEL) staining of harvested xenografts revealed that upregulation of FOXD2-AS1 increased laryngeal cancer cell proliferation, and significantly decreased cell apoptosis level in LSCC (Fig. 3d, e). Here, FOXD2 is linked to laryngeal carcinoma.