This category included genes involved in fatty acid synthesis (FASN,ACACA); the peroxisome proliferator-activated receptors (PPAR) pathway whose members regulate glycolysis, lipid metabolism, and adipogenesis; inflammatory chemokine signal pathways; recently discovered drivers of NASH, particularly HAO2, a hydroxyacid oxidase, and monoacylglycerol acyltransferase (Mogat1); [27, 28] and a large cluster of genes involved in NAFLD. Here, ACACA is linked to metabolic dysfunction-associated steatohepatitis.