RIP and the MS2-tagged RNA affinity assay revealed that WFDC21P could interact strongly with PFKP (Fig. 5g), the main phosphofructokinase (PFK) isoform in HCC cells (Supplementary Fig. 5e), and PKM2 (Fig. 5h), while it demonstrated faint interaction with GAPDH and no interaction with hexokinase 2 (HK2) (Supplementary Fig. 5f, g), in line with the results obtained by mass spectrometry. This evidence concerns the gene GAPDH and hepatocellular carcinoma.