ATP7A and amyotrophic lateral sclerosis: Because ALS is known to be a multifactorial disease and over 100 genes are intricately involved29,56–58, the ATP7A gene may act as one crucial component in an ALS-related network and the ALS disease may be caused by a combination of other disease factors such as genetic defects of other variants in a patient’ genome, altered transcripts, and epigenetic and environmental factors together with ATP7A M1311V59–62.