In our results of trio-based WGS, the patient had many genetic variants in addition to the variants in ATP7A. Although we prioritized the ATP7A M1311V mutation as a strong candidate for ALS pathogenesis because of its higher pathogenic score and the X-linked recessive mutation, we could not exclude other variants completely, which might be a further study. Here, ATP7A is linked to amyotrophic lateral sclerosis.