The dementia relevant Bri2 and its BBB permeable BRICHOS domain are associated with AD: Bri2 is produced in the CNS in the same cells as the Aβ precursor protein AβPP, colocalizes with senile plaques, interacts with Aβ in neurons, and increased amounts of different Bri2 forms have been found in human AD brains38,39,48. This evidence concerns the gene APP and dementia.