SPINK1 and prostate adenocarcinoma: Thus, we sought to discover the possible link between SPINK1 and AR expression in PCa patients, and stratified patients available at TCGA-PRAD (The Cancer Genome Atlas Prostate Adenocarcinoma) cohort based on high and low expression of AR. The patients with higher expression of AR showed a significantly lower expression of SPINK1 and contrariwise (Fig. 1a).