We also examined CD117 (c-KIT), a tyrosine kinase receptor associated with cancer progression and stem-cell maintenance16, and a reduction in the percent c-KIT positive cells was observed in the 22RV1-shSPINK1 cells, while an increase was noted in SPINK1 overexpressing LNCaP cells (Fig. 4j). The gene discussed is SPINK1; the disease is cancer.