One of the aims of the study was to examine the clinical potential of both genes as predictive factors regarding radiotherapy, and the sub-analysis indicated that, in contrast to tumours with S6K1 amplification, tumours with a normal S6K1 gene copy number responded better to radiotherapy compared to chemotherapy (HR 0.27, 95% CI: 0.11–0.66, p = 0.0038)20. Here, RPS6KB1 is linked to neoplasm.