AKT1 and schizophrenia: Given that lithium antagonizes dopaminergic neurotransmission and behaviors mediated by the Akt-Gsk3 signaling pathway and that AKT1 has been identified as a possible schizophrenia susceptibility gene, we further clarified the effect of lithium in an Akt1 mouse model of schizophrenia and Akt1-deficient neuronal cells.