IGFBP7 and neoplasm: For example, expression of IGFBP7 was insignificant in whole tumour analysis while homogenous stromal analysis showed significantly higher expression of IGFBP7 in both primary tumour and metastasis with 2.719 (p ≤ 0.05) and 12.46 (p ≤ 0.01) fold increase respectively when compared to normal stroma.