TNF and colon carcinoma: Similarly, the Receptor-interacting protein kinase 1 (RIPK1)-inhibitor Necrostatin1 (Nec1)57 did not rescue STF-62247- or pimozide-induced cell death (Fig. 6D,E), while a control experiment confirmed that Nec1s provided complete protection in a prototypic model of necroptosis (Fig. 6F), using treatment with the combination of tumor necrosis factor α (TNFα), the Smac mimetic BV6 and zVAD.fmk (TBZ) in HT-29 colon carcinoma cells58.