Besides affecting the autophagic flux, VHL-deficiency was also reported to promote killing of renal cell carcinoma cells either by treatment with low doses of STF-62247 alone (<1.25 μM) or in combination with radiotherapy, whereas the concentrations of STF-62247 used in the present study were markedly higher (20–40 μM)82. Here, VHL is linked to hereditary clear cell renal cell carcinoma.