The TYR gene is the causal gene of human oculocutaneous albinism type 1 (OCA1)15, a single C·G to T·A base pair conversion was designed in exon 1 of the rabbit Tyr gene for the purpose of yielding a premature stop codon (p. Q68stop) (Fig. 3a). Here, TYR is linked to oculocutaneous albinism type 1.