However, shNEDD4L tumors from CQ-injected mice, showed significant increase of the levels of Caspase 3, a cell death marker compared to shNEDD4L tumors from vehicle-injected mice, suggesting that autophagy inhibition effectively blocks tumor growth through stimulation of cell death mechanism, particularly in NEDD4L-depleted tumors (Fig. S10). The gene discussed is CASP3; the disease is neoplasm.