PDX1 and pancreatic ductal adenocarcinoma: Furthermore, we observed significant inverse correlation between NEDD4L and ULK1 levels in the pancreatic regions from spontaneous pancreatic ductal adenocarcinoma (PDAC) mouse model driven by KrasLSL-G12D/+; Trp53LSL-R172H/+; Pdx1-Cre (KPC).