TP53 and small cell lung carcinoma: Current studies have shown that SCLC has no clear target–driver gene mutations, and almost all SCLCs have none or inactivated TP53 and RB1 [17] Thirteen DNAH10 mutations were identified in 66 (19.7%) SCLC cell lines, and six mutations were found in 110 (5.50%) patients with SCLC.