Therefore, we hypothesized that the negative regulation of FGFR, the SPRY regulation of FGF, and the positive regulation of noncanonical WNT and PI3K/AKT/IKK signaling pathways may be the key pathway regulated by DNAH10 mutation for promoting cisplatin resistance in DNAH10-mutated SCLC cell lines. This evidence concerns the gene DNAH10 and small cell lung carcinoma.