IFNG and neoplasm: In tumor-bearing mice, adoptively transferred effector T cells lacking IFN-γ displayed impaired antitumor responses.35 IFN-γ may also mediate the antitumor effects of IL-12 and was required for antitumor immunity mediated by antigen-specific T cells expressing secreted IL-12.32 36 In our current study, we have demonstrated that in vitro T cells modified by aIL-12 increased IFN-γ production, similar to cells with secreted IL-12, which suggests that these two different forms of IL-12 have similar functions.