Actually, other B7 family members, such as B7-H3 and B7x, or other immunosuppressive factors such as metabolites (eg, adenosine, IDO), also contribute to immunosuppression in the tumor microenvironment.30–32 Therefore, an immunophenotyping system containing other B7 family members is needed to guide clinical immunotherapy. The gene discussed is CD276; the disease is neoplasm.