Using murine CD80 negative SCC and pancreatic cancer cell lines that exhibit little response to BI 853520, we show that the combination of BI 853520 together with agonistic antibodies targeting other T-cell co-stimulatory receptors, in particular OX40 and 4-1BB, results in enhanced anti-tumor immunity and even complete CD8 T-cell dependent tumor regression leading to lasting immunological memory. Here, CD8A is linked to neoplasm.