PTK2 and pancreatic neoplasm: The discovery of a role for FAK in regulating the immuno-suppressive TME in mouse models of skin squamous cell carcinoma (SCC) (Serrels et al., 2015) and pancreatic cancer (Jiang et al., 2016; Stokes et al., 2011) has resulted in a shift in the clinical development of FAK kinase inhibitors, with new focus towards immune oncology.