To determine whether the potent anti-tumor efficacy of BI 853520 + anti-OX40 was dependent on CD8 T-cells, we depleted CD8 T-cells using an anti-CD8 antibody, and measured SCC6.2 tumor growth in FVB/N mice receiving either Vehicle or BI 853520 + anti-OX40 (Figure 5F). This evidence concerns the gene TNFRSF4 and neoplasm.