Microglial and OPC TRCs shared 8 DETFs (Irf8, Cebpa, Jun, Rela, Stat3, Spi1, Cebpb, and Srebf1) and 18 target genes (Ccl3, Cd14, Csf1, Csf1r, C3ar1, Nupr1, Hmox1, Icam1, Itgam, Blnk, Gadd45g, Il10rb, Lyn, Tlr7, Tgfb1, Trf, Tnfrsf1, and Dab2) that appear to be more relevant to prion diseases than other genes in the TRCs. Here, IRF8 is linked to prion disease.