We finally identified a set of ten methylation-related genes (SCNN1B, NFE2L3, CLDN2, RBPMS2, JPH2, GBP6, COL4A5, SMKR1, PPP1R14A, and ARL4D) that showed differential expression among the GC patients from TCGA. Here, COL4A5 is linked to gastric cancer.