In this study, we performed an integrative analysis to identify the epigenetic changes that may play key role in the initiation and progression of GC, based on which we developed a DNA methylation signature consisting of ten gene members (SCNN1B, NFE2L3, CLDN2, RBPMS2, JPH2, GBP6, COL4A5, SMKR1, PPP1R14A, and ARL4D) to improve survival prediction of GC. This evidence concerns the gene RBPMS2 and gastric cancer.