We found that miR-27b-3p and miR-340-5p significantly decreased luciferase activity driven by wt-VAV3 but not by mut-VAV3 (Fig. 4c), indicating that VAV3 mRNA levels are directly regulated by miR-27b-3p/miR-340-5p in NSCLC cells. Here, VAV3 is linked to non-small cell lung carcinoma.