In the hilus and dentate gyrus of patients with structural epilepsy, the intensity of the HMGB1 staining proved to be reduced in comparison with one of the control groups (hilus: F (3, 41) = 5.605, p = 0.0028; CTRpat vs. Structural p < 0.05 and dentate gyrus: F (3, 43) = 6.189, p = 0.0015; CTRexp vs. Structural p < 0.05; see Fig. 2h and i). The gene discussed is HMGB1; the disease is structural epilepsy.