The analysis of correlation between HSP70 and NeuN expression in control (CTRexp and CTRpat) and dogs with epilepsy (Structural and Idiopathic) indicated no correlation in CTR (Pearson correlation coefficient r = 0.5372, p = 0.0717) and a negative trend in dogs with epilepsy (Pearson correlation coefficient r = − 0.6915, p = 0.0852). This evidence concerns the gene RBFOX3 and epilepsy.