HMGB1 expression did neither correlate with neuronal density in control animals (CTRexp and CTRpat: Pearson correlation coefficient r = − 0.08606, p = 0.7426) nor in animals with epilepsy (Structural and Idiopathic: Pearson correlation coefficient r = 0.08736, p = 0.7766). This evidence concerns the gene HMGB1 and epilepsy.