Among the DGC-associated muscular dystrophies are Duchenne/Becker muscular dystrophies (DMD/BMD), resulting from mutations in the cytoplasmic protein dystrophin that connects actin cytoskeleton to the muscle membrane; limb-girdle muscular dystrophies (LGMDs), caused by the dysfunction of the membrane-associated dystroglycan and sarcoglycan multiprotein complexes; and congenital muscular dystrophies (CMDs), triggered by the deregulation of dystroglycan and the ECM protein laminin (Fig. 1a). This evidence concerns the gene DAG1 and muscular dystrophy.