To identify the conserved gene signature conferred by IL-1 in HR+ BCa and PCa cells that mimics intrinsic gene expression patterns in HR− BCa and PCa cells, we performed RNA sequencing (RNA-seq) followed by differential gene expression analysis (log2 CPM ≥ 0, log2 FC ≥ 0.6 or ≤ − 0.6, and FDR ≤ 0.05) for IL-1α- or IL-1β-treated ERα+/PR+ MCF7 BCa cell line, IL-1β-treated AR+ LNCaP PCa cell line, vehicle control-treated ERα−/PR− MDA-MB-231 BCa cell line, and vehicle control-treated AR− PC3 PCa cell line. The gene discussed is IL1A; the disease is posterior cortical atrophy.