AR+ LNCaP PCa cells and ERα+ MCF7 BCa cells were first transfected with p62 or SOX9 siRNA and the following the day, treated with vehicle control, 25 ng/ml IL-1α, or 25 ng/ml IL-1β for 3 days (LNCaP, MCF7) or 5 days (MCF7). The gene discussed is ESR1; the disease is posterior cortical atrophy.