Interestingly, an increased risk for IRIS onset among TB-HIV co-infected individuals was found among those having a CD8 count ≤500 cells/mm3; carrying the KIR2DS2, the HLA-B*41, and the KIR2DS1 + HLA-C2 pair; as well as not carrying KIR2DL3 + HLA-C1/C2 and KIR2DL1 + HLA-C1/C2 pairs (Table 3). The gene discussed is CD8A; the disease is tuberculosis.