A previous meta-analysis established a pooled CrAg positivity prevalence of 2.0% for PLWH with CD4 100–200 cells/mm3 [7], and recent data from sub-Saharan Africa suggests that at least 9% of cases of cryptococcal meningitis present in individuals with CD4 > 100 cells/mm3 [8, 9]. Here, CD4 is linked to Cryptococcal meningitis.