Among participants with CD4 < 100 cells/mm3 (N = 179), four of ten (IR: 64.7 per 100 person-years) CrAg positive participants and 26 of 169 (IR: 19.7 per 100 person-years) CrAg negative participants died, and four of ten (IR: 78.6 per 100 person-years) CrAg positive participants and 1 of 169 (IR: 0.7 per 100 person-years) CrAg negative participants developed cryptococcal meningitis. This evidence concerns the gene CD4 and Cryptococcal meningitis.