We also postulated that ERS‐mediated apoptosis would be further enhanced in response to disruption of MUC2 protein homeostasis by PI3K inhibition since PI3K‐AKT‐depedent fatty acid synthase (FASN) activity is essential for appropriate MUC2‐palmitoylation and secretion.26 Finally, we postulated that dual cytotoxic and MUC2‐suppressive properties of combined MAPK‐PI3K pathway inhibition would be advantageous in these mucinous tumors.27, 28, 29. This evidence concerns the gene MUC2 and mucinous neoplasm.