Genotypically, these tumors frequently demonstrate KRAS mutations, resulting in downstream activation of MAPK and PI3K signaling pathways.9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 Phenotypically, mucinous tumors demonstrate high basal endoplasmic reticulum stress (ERS), and associated signaling pathways known as the upregulated protein response (UPR), likely due to high mucin 2 (MUC2) protein turnover.20, 21, 22, 23 Therefore, they are likely to be vulnerable to aggravated ERS‐associated apoptosis. This evidence concerns the gene KRAS and mucinous neoplasm.