27 As shown in Figure 4D, PBSA markedly inhibited mitogen‐induced MKK3/6 phosphorylation to the levels observed in the untreated controls. These data suggest that anti‐invasive and anti‐proliferative activities of PBSA against ovarian cancer cells are mediated, at least in part, through the inhibition of integrin β1 expression and inactivation of MKK3/6‐p38MAPK‐dependent signalling pathway. The gene discussed is MAP2K3; the disease is ovarian cancer.