The mechanism of these anti‐cancer and anti‐angiogenic activities of PBSA involves inactivation of MKK3/6‐p38MAPK‐dependent signalling pathways and subsequent down‐regulation of MMP‐9, MMP‐2, Cdk4, Cdk2, integrin β1 and VEGF expression, which are closely associated with cancer cell growth and progression as well as angiogenesis. Here, CDK4 is linked to cancer.