In the tumour microenvironment, cancer cells produce and secrete numerous biologically active molecules such as growth factors and cytokines, which are closely associated with angiogenic and metastatic responses.28, 29, 30 We analysed the changes in the expression and secretion of a key angiogenic factor VEGF in PBSA‐treated SKOV‐3 cells. The gene discussed is VEGFA; the disease is cancer.